Young Investigator Subcommittee
In August 2020, the Young Investigator Subcommittee called for Young Investigators from across the globe in the field of genomic medicine who were interested in becoming involved with G2MC through guided leadership and coordinated activities and efforts. The subcommittee convened in November 2020 to review submissions of interested participants and identified 29 dedicated Young Investigators with specific areas of interest and expertise in genomic medicine. The subcommittee co-chairs are currently working with G2MC Working Group and Flagship Project co-chairs to match the Young Investigators with G2MC projects and initiatives in which they may best contribute their knowledge and skills.
Additionally, the subcommittee is in the process of planning for the Young Investigators component of the 2021 International Conference, taking into account the previous postponement of this event due to the 2020 International Conference shifting to a full virtual meeting. Updates on this and other Young Investigator activities will be discussed during the January 19 Young Investigator Committee Breakout Session.
Evidence Working Group
The Evidence Working Group has been working on an evidence review of the clinical utility of genomic medicine, an effort that was kick-started during the May 2020 G2MC International Conference Virtual Breakout Sessions. The group has been tailoring search terms and working with experts on best practices to ensure all relevant evidence is captured. Results and updates from the review process will be shared during the January 27 Evidence Working Group Breakout Session.
The next steps for the group are to engage with technology partners to develop an Artificial Intelligence (AI) system that will allow for better refined searches and automatic updates in the areas deemed significant from the systematic review. The group also plans to engage a Young Investigator on this project as well as several other areas specific to the group’s needs in the coming months.
Education Working Group
The Education Working Group is actively seeking and discussing project ideas from both within the WG and related to other WGs and Flagship Projects. It is hoped that members will take leadership roles on projects with integration of the WG Young Investigators. The group is also continuing the planning of the Genomic Medicine Immersion Course scheduled to take place as part of the 2021 G2MC International Conference in Santiago, Chile and is reviewing options for formatting and topics to include in the course. These items will be discussed in further detail during the January 25 Education Working Group Breakout Session.
Additionally, writing of the manuscript resulting from the Education Needs Assessment Survey is in process with plans to be completed and submitted for publication in the next few months.
Policy Working Group
The Policy Working Group is exploring potential collaborations and initiatives for growing the online catalogue of global genomic medicine initiatives, a resource established in partnership with the Australian Genomics Health Alliance. The Genomics Policy Website that houses the catalogue and was recently managed by the Australian group, is now under G2MC ownership and the group will be seeking a G2MC member or Young Investigator interested in managing and updating this site moving forward. The group is also working towards the development of a roadmap for implementation of genomic medicine which will outline policy issues for consideration, and is also continuing to identify opportunities for supporting the G2MC Flagship Projects.
Additionally, in September 2020 an article authored by several G2MC members titled “Global approaches to genomic medicine implementation” was published in Translational Medicine that focuses on similarities in policy considerations of G2MC and other genomic medicine groups worldwide.
The Policy Working Group is currently looking for a volunteer interested in taking on a leadership role within the group to help move the group’s mission and initiatives forward. They are also looking for Young Investigators interested in being involved with the group’s projects. Members may use the G2MC Get Involved form to indicate interest.
Pharmacogenomics Flagship Project
The Pharmacogenomics Flagship Project has been exploring opportunities with the Evidence Working Group on ways to demonstrate existing evidence in the field of pharmacogenomics. Additionally, the project will focus efforts on the need for generating harmonized guidelines for pharmacogenomics in clinical use – an area that is already under exploration but can potentially be advanced further through the efforts of the flagship project group. These initiatives will be discussed further during the January 21 Pharmacogenomics Flagship Project Breakout Session.
Rare Undiagnosed Diseases Flagship Project
The Rare Undiagnosed Diseases Flagship Project is working towards implementing evidence-based exome sequencing for the diagnosis of rare uncharacterized and undiagnosed diseases in low and middle-income countries (LMICs). Following the May 2020 G2MC International Meeting the group put out a call for LMIC sites interested in participating in the project, resulting in 16 sites from across 4 continents expressing interest. Collaborative measures are being put into place for information sharing and the establishment of guidelines to get the sites appropriately set up. The group is in the process of securing additional financial and in-kind support, and plans to also seek collaborative opportunities with G2MC Working Groups and pharmaceutical groups outside of G2MC for participation. An overview of current activities and steps moving forward will be discussed during the January 26 Rare Disease Flagship Project Breakout Session. Learn more about the Rare Undiagnosed Disease Flagship Project.
Family Health History Flagship Project
The Family Health History Flagship Project has published a webpage to provide continuous updates and engage the community in efforts being carried out by the group. In order to advance the project’s mission, the group is planning to use the website and other outreach materials to engage groups outside of G2MC in partnerships and projects. Additionally, three Young Investigators with a focused interest in genealogy and family health history have been identified to assist with and lead activities within the group. As part of the January 29 Family Health History Flagship Project Breakout Session, these Young Investigators will participate by discussing their needs around family health history in their countries.